A putative gene cluster for aminoarabinose biosynthesis is essential for Burkholderia cenocepacia viability |
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| Authors: | Ortega Ximena P Cardona Silvia T Brown Alan R Loutet Slade A Flannagan Ronald S Campopiano Dominic J Govan John R W Valvano Miguel A |
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| Affiliation: | Department of Microbiology and Immunology, Infectious Diseases Research Group, Siebens-Drake Medical Research Institute, University of Western Ontario, London, Ontario, Canada. |
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| Abstract: | Using a conditional mutagenesis strategy we demonstrate here that a gene cluster encoding putative aminoarabinose (Ara4N) biosynthesis enzymes is essential for the viability of Burkholderia cenocepacia. Loss of viability is associated with dramatic changes in bacterial cell morphology and ultrastructure, increased permeability to propidium iodide, and sensitivity to sodium dodecyl sulfate, suggesting a general cell envelope defect caused by the lack of Ara4N. |
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