Effect of human leukocyte interferon on human lymphocytes in vitro: cytogenetic studies |
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| Authors: | Karam El-Bayoumy Edmond J. Lavoie Stephen S. Hecht Elizabeth Ann Fow Dietrich Hoffmann |
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| Affiliation: | Division of Environmental Carcinogenesis, Naylor Dana Institute for Disease Prevention, Valhalla, New York 10595, NY U.S.A. |
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| Abstract: | Mitogen-stimulated lymphocytes from 8 healthy donors were exposed to interferon, and cytogenetic studies were preformed. The response of lymphocytes to the mitogens phytohemagglutinin (PHA), concanavalin A (con A) and pokeweed mitogen (PWM) was inhibited by interferon, whereas an increased number of structural chromosomal aberrations was not detected. Further investigations of the cytogenetic effects of interferon are needed. |
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