Mycotic Keratitis Caused by <Emphasis Type="Italic">Fusarium solani sensu stricto</Emphasis> (FSSC5): A Case Series |
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| Authors: | Hazal Boral Anne van Diepeningen Elif Erdem Meltem Ya?mur G Sybren de Hoog Macit Ilkit Jacques F Meis Abdullah M S Al-Hatmi |
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| Institution: | 1.Division of Mycology, Department of Microbiology, Faculty of Medicine,University of ?ukurova,Adana,Turkey;2.BU Biointeractions and Plant Health,Wageningen University and Research,Wageningen,The Netherlands;3.Department of Ophthalmology, Faculty of Medicine,University of ?ukurova,Adana,Turkey;4.Westerdijk Fungal Biodiversity Institute,Royal Dutch Academy of Arts and Sciences,Utrecht,The Netherlands;5.Centre of Expertise in Mycology Radboud University Medical Centre/Canisius Wilhelmina Hospital,Nijmegen,The Netherlands;6.Department of Medical Microbiology and Infectious Diseases and ECMM Excellence Center for Medical Mycology,Canisius Wilhelmina Hospital,Nijmegen,The Netherlands;7.Ministry of Health, Directorate General of Health Services,Ibri,Oman |
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| Abstract: | Owing to a lack of appropriate diagnostic and therapeutic approaches for mycotic keratitis, approximately one million cases of preventable corneal blindness are reported each year. The number of keratitis cases due to infection with Fusarium is increasing significantly worldwide, many of which are not treated adequately and in a timely manner due to frequent misdiagnosis. In the current report, we describe three cases of keratitis caused by Fusarium solani sensu stricto (FSSC5) from Turkey and The Netherlands, following ocular trauma. The etiological agent of keratitis, FSSC5, identified by sequencing of the partial tef1-α gene, exhibited low minimum inhibitory concentrations (MICs) of 1 µg/mL for amphotericin B and high MICs above the published epidemiological cutoff values for voriconazole (8 µg/mL). Patients were successfully treated with topical amphotericin B and voriconazole with complete recovery. |
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