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Angiostrongylus cantonensis: Biogenic amines in the lungs of infected rats
Authors:Yawaluck Tiengkamol  Chariya R Brockelman
Institution:Department of Microbiology, Faculty of Science, Mahidol University, Bangkok, Thailand
Abstract:Levels of histamine, serotonin, norepinephrine, and dopamine were estimated sequentially in rats parasitized by the lungworm, Angiostrongylus cantonensis, between 30 and 75 days postinfection. The highest level of histamine in the infected lungs was 52.19 μg/g wet wt tissue, 13 times higher than the level found in control rats. The level of serotonin rose from the normal level of 6.41 to 10.27 μg/g wet wt tissue after the worms had lodged in the pulmonary artery for 15 days. There were no changes in norephinephrine or dopamine. Studies of host cell response to infection revealed that the increased histamine and serotonin levels corresponded to a rise in the lung population of mast cells, suggesting that these cells produced the amines.
Keywords:Nematode  parasitic  Amines  biogenic  Rat  Lung  Mast cells
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