Ascaris suum: Differential effects of Avermectin B1a on the intact animal and neuromuscular strip preparations |
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| Authors: | Ira S Kass David A Larsen Ching C Wang Antony OW Stretton |
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| Institution: | Department of Zoology, University of Wisconsin, Madison, Wisconsin 53706, U.S.A.;Merck Institute for Therapeutic Research, Rahway, New Jersey 07065, U.S.A.;Department of Zoology, University of Wisconsin, Madison, Wisconsin 53706 U.S.A. |
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| Abstract: | Avermectin B1a, a novel antiparasitic agent, paralyzes Ascaris suum without causing either flaccid paralysis or a hypercontraction. It reduces the lengthening of the acetylcholine-preconditioned A. suum muscle strip caused by γ-aminobutyric acid. It does not affect the contraction of the isolated muscle strip preparation caused by applying acetylcholine. However, preinjection with Avermectin B1a does significantly reduce the shortening caused by acetylcholine injection without affecting the paralysis of an intact ascarid worm. These results suggest that Avermectin B1a may act on the central nervous system of Ascaris sp. nematodes. |
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| Keywords: | Nematode parasitic Motorneurons Interneurons Neuromuscular system Macrolide Anthelmintic γ-aminobutyric acid Picrotoxin Muscimol |
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