Trafficking and cellular distribution of voltage-gated sodium channels |
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Authors: | Cusdin Fiona S Clare Jeffrey J Jackson Antony P |
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Affiliation: | Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK. |
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Abstract: | Electrical excitability in cells such as neurons and myocytes depends not only upon the expression of voltage-gated sodium channels but also on their correct targeting within the plasma membrane. Placing sodium channels within a broader cell biological context is beginning to shed new light on a variety of important questions such as the integration of neuronal signaling. Mutations that affect sodium channel trafficking have been shown to underlie several life-threatening conditions including cardiac arrhythmias, revealing an important clinical context to these studies. |
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Keywords: | axon initial segment binding motifs cardiac myocyte endocytosis neuron node of Ranvier voltage-gated sodium channels |
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