Localization of the locus causing Spider Lamb Syndrome to the distal end of ovine Chromosome 6 |
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| Authors: | NE Cockett TL Shay JE Beever D Nielsen J Albretsen M Georges K Peterson A Stephens W Vernon O Timofeevskaia S South J Mork A Maciulis TD Bunch |
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| Institution: | (1) Department of Animal, Dairy & Veterinary Sciences, Utah State University, Logan, Utah 84322-4700, USA, US;(2) Department of Animal Science, University of Illinois, Urbana, Illinois 61801, USA, US;(3) Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695-7614, USA, US;(4) National Animal Poison Control Center, Urbana, Illinois 61802, USA, US;(5) Department of Genetics, College of Veterinary Medicine, University of Liége, 4000 Liége, Belgium, BE;(6) Center for Persons with Disabilities, Utah State University, Logan, Utah 84322-6800, USA, US |
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| Abstract: | Spider Lamb Syndrome (SLS) is a semi-lethal congenital disorder, causing severe skeletal abnormalities in sheep. The syndrome
has now been disseminated into several sheep breeds in the United States, Canada, and Australia. The mode of inheritance for
SLS is autosomal recessive, making the identification and culling of carrier animals difficult due to their normal phenotype.
Two large pedigrees segregating for the SLS mutation were established, and a genome scan with genetic markers from previously
published genome maps of cattle and sheep was used to map the locus causing SLS. Genetic linkage between SLS and several microsatellite
markers, OarJMP8, McM214, OarJMP12, and BL1038, was detected, thereby mapping the SLS locus to the telomeric end of ovine Chromosome (Chr) 6. Alignment of ovine Chr 6 with
its evolutionary ortholog, human Chr 4, revealed a positional candidate gene, fibroblast growth factor receptor 3 (FGFR3).
Received: 10 June 1998 / Accepted: 23 September 1998 |
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