Determination of Glucose Concentration in Whole Blood using Fourier-Transform Infrared Spectroscopy |
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| Authors: | Y.C. Shen A.G. Davies E.H. Linfield P.F. Taday D.D. Arnone T.S. Elsey |
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| Affiliation: | (1) Cavendish Laboratory, University of Cambridge, Madingley Road, Cambridge, CB3 0HE, UK;(2) School of Electronic and Electrical Engineering, University of Leeds, Leeds, LS2 9JT, UK;(3) Clinical Biochemistry, Addenbrooke's NHS Trust, Cambridge, CB2 2QR, UK |
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| Abstract: | Fourier-transform infrared(FTIR) transmission spectroscopy has beenused for the determination of glucoseconcentrations in whole blood samples fromtwenty-eight patients. A four-vectorpartial least squares calibration model,using the spectral range 950–1200 cm-1,yielded a standard error of prediction of0.59 mM for an independent test set. Forblood samples from a single patient, wefound that the glucose concentration wasproportional to the difference between thevalues of the second derivative spectrum at1082 cm-1 and 1093 cm-1, suggestingthat these two specific wavelengths can beused for determining glucose concentrationsin blood. |
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| Keywords: | Blood Fourier transform glucose infrared spectroscopy |
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