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SLC45A4 promotes glycolysis and prevents AMPK/ULK1-induced autophagy in TP53 mutant pancreatic ductal adenocarcinoma |
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| Authors: | Wenying Chen Fengting Huang Jing Huang Yuanhua Li Juanfei Peng Yanyan Zhuang Xianxian Huang Liting Lu Zhe Zhu Shineng Zhang |
| Affiliation: | 1. Department of Gastroenterology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China Department of Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China;2. Department of Gastroenterology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China;3. Department of General Surgery, Peking University Shenzhen Hospital, Shenzhen, China;4. Department of Gastroenterology, Tungwah Hospital of Sun Yat-Sen University, Dongguan, China;5. Department of Gastroenterology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China;6. Center of Digestive Endoscopy, The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China;7. Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA |
| Abstract: | |
| Keywords: | AMPK pathway autophagy glucose metabolism SLC45A4 TP53 mutation |