Effect of Hoechst 33258 on Chinese hamster chromosomes |
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Authors: | A. Rocchi G. Prantera S. Pimpinelli M. Di Castro |
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Affiliation: | (1) Istituto di Genetica e Centre di Genetica Evoluzionistica del CNR, Università di Roma, Città Universitaria, 00185 Roma, Italia |
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Abstract: | Cells of the Chinese hamster strain C-125 were treated for different time intervals with H 33258, a bibenzimidazole derivative. The same compound was used to stain fixed cells of the same strain. — H 33258 induced in cells in culture specific areas of reduced spiralization on the metaphase chromosomes of some cells. These probably correspond to DNA segments rich in A-T bases interspersed along the chromosomes. Probably H 33258 acts during S period of cell cycle. — The banding obtained by staining with H 33258 is similar to that induced by quinacrine dihydrochloride but shows a better resolution. |
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