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Congenital Abnormalities and Multiple Sclerosis |
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| Authors: | Sreeram V Ramagopalan Colleen Guimond Maria Criscuoli David A Dyment Sarah-Michelle Orton Irene M Yee George C Ebers Dessa Sadovnick |
| Affiliation: | 1.Wellcome Trust Centre for Human Genetics,University of Oxford,Oxford,UK;2.Department of Clinical Neurology,University of Oxford, The West Wing, The John Radcliffe Hospital,Oxford,UK;3.Department of Medical Genetics,University of British Columbia, G920, Detwiller Pavilion, VCHA - UBC Hospital,Vancouver,Canada;4.Faculty of Medicine, Division of Neurology,University of British Columbia, G920, Detwiller Pavilion, VCHA - UBC Hospital,Vancouver,Canada |
| Abstract: | BackgroundThere is a strong maternal parent-of-origin effect in determining susceptibility to multiple sclerosis (MS). One hypothesis is that an abnormal intrauterine milieu leading to impaired fetal development could plausibly also result in increased susceptibility to MS. A possible marker for this intrauterine insult is the presence of a non-fatal congenital anomaly. |
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