Antioxidant Properties of Bromocriptine, a Dopamine Agonist |
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Authors: | Toshikazu Yoshikawa&dagger ,Yukiko Minamiyama,Yuji Naito,Motoharu Kondo |
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Affiliation: | First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto;Research Center for Advanced Science and Technology, University of Tokyo, Tokyo, Japan |
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Abstract: | Abstract: It has been suggested that free radicals may adversely influence the pathogenesis of Parkinson's disease. We conducted this study to determine whether bro-mocriptine, an agent widely used for treating parkinsonism, possesses antioxidant effects. Bromocriptine scavenged superoxide produced from a superoxide generating system (hypoxanthine-xanthine oxidase) by the spin-trapping method using electron spin resonance. Bromocriptine had a strong scavenging effect on the 5,5-dimethyl-1-pyrroline- N -oxide hydroxide signal produced from Fenton's reaction. Bromocriptine also attenuated the stable free radical diphenyl- p -picrylhydrazyl signal. This drug inhibited the autooxidation of rat brain homogenates in a dose-dependent manner in vitro. Autooxidation of brain homogenates collected from rats treated with bromocriptine (2.5 mg/kg, i.p., daily for 3 days) was significantly reduced as compared with values in untreated rat homogenates. These observations suggest that bromocriptine is a free radical scavenger and a potent antioxidant. |
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Keywords: | Bromocriptine Parkinson's disease Free radicals Antioxidant Electron spin resonance |
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