A Speckle-Free Angular Interrogation SPR Imaging Sensor Based on Galvanometer Scan and Laser Excitation |
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Authors: | Zeng Youjun Zhou Jie Xiao Xiaoping Wang Lei Qu Junle Li Xuejin Gao Bruce Zhi Shao Yonghong |
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Affiliation: | 1.College of Optoelectronics Engineering, Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, Shenzhen Key Laboratory of Sensor Technology, Shenzhen University, Shenzhen, 518060, China ;2.Hunan Institute of Metrology & Test, Changsha, 410014, Hunan, China ;3.Department of Bioengineering and COMSET, Clemson University, Clemson, SC, 29634, USA ; |
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Abstract: | A speckle-free fast angular interrogation surface plasmon resonance imaging (SPRi) sensor based on a diode-pumped all-solid-state laser and galvanometer is reported in this work. A bidirectional scan using a galvanometer realizes the fast scanning of the incidence angle. The experimental results showed that the time needed for completing an SPR dip measurement was decreased to 0.5 s. And through cascading an immovable diffuser and two diffusers rotating in opposite directions, laser speckle was eliminated. The dynamic detection range and the sensitivity reached 4.6 × 10−2 and 1.52 × 10−6 refractive index unit (RIU), respectively, in a 2D array sensor when the angle scanning range was set as 7.5°. More importantly, the results demonstrated that the angular interrogation SPR imaging sensor scheme had the capability to perform fast and high-throughput detection of biomolecular interactions at 2D sensor arrays. |
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