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Early Detection of G + C Differences in Bacterial Species Inferred from the Comparative Analysis of the Two Completely Sequenced Helicobacter pylori Strains |
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| Authors: | Matthew Bellgard David Schibeci Edward Trifonov Takashi Gojobori |
| Institution: | (1) Centre for Bioinformatics and Biological Computing, School of Information Technology, Murdoch University, Murdoch, WA, 6150, Australia, AU;(2) Department of Structural Biology, The Weizmann Institute of Science, Rehovot, Israel, IL;(3) Center for Information Biology, National Institute of Genetics, Mishima, Japan, JP |
| Abstract: | Identifying the G + C difference between closely related bacterial species or between different strains of the same species is one of the first steps in understanding the evolutionary mechanisms accounting for the differences observed among bacterial species. The G + C content can be one of the most important factors in the evolution of genomic structures. In this paper, we describe a new method for detecting an initial stage of differentiation of the G + C content at the third codon base position between two strains of the same bacterial species. We apply this method to the two strains of Helicobacter pylori. A group of genes is detected with large variations of G + C in the third positions—apparently genes of early response to pressures of changing G + C. We discuss our findings from the viewpoint of genomic evolution. Received: 26 February 2001 / Accepted: 16 May 2001 |
| Keywords: | : G + C content — Complete genome sequences — Helicobacter pylori |
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