Macrophages Generate Pericytes in the Developing Brain |
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Authors: | Pedro H. D. M. Prazeres Viviani M. Almeida Luiza Lousado Julia P. Andreotti Ana E. Paiva Gabryella S. P. Santos Patrick O. Azevedo Luanny Souto Gregório G. Almeida Renato Filev Akiva Mintz Ricardo Gonçalves Alexander Birbrair |
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Affiliation: | 1.Department of Pathology,Federal University of Minas Gerais,Belo Horizonte,Brazil;2.Laboratory of Neurobiology,Federal University of S?o Paulo,S?o Paulo,Brazil;3.Department of Radiology,Columbia University Medical Center,New York,USA |
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Abstract: | Pericytes are defined by their anatomical location encircling blood vessels' walls with their long projections. The exact embryonic sources of cerebral pericytes remain poorly understood, especially because of their recently revealed diversity. Yamamoto et al. (Sci Rep 7(1):3855, 2017) using state-of-the-art techniques, including several transgenic mice models, reveal that a subpopulation of brain pericytes are derived from phagocytic macrophages during vascular development. This work highlights a new possible ancestor of brain pericytes. The emerging knowledge from this research may provide new approaches for the treatment of several neurodevelopmental disorders in the future. |
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