Expression of the blood-group-related antigens Sialyl Lewis a,Sialyl Lewis x and Lewis y in term placentas of normal,preeclampsia, IUGR- and HELLP-complicated pregnancies |
| |
Authors: | Vassilis Minas Ioannis Mylonas Barbara Schiessl Doris Mayr Sandra Schulze Klaus Friese Udo Jeschke Antonis Makrigiannakis |
| |
Affiliation: | (1) Laboratory of Human Reproduction, Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Crete, 71003 Heraklion, Greece;(2) First Department of Obstetrics and Gynaecology, Ludwig-Maximilians-University of Munich, Maistrasse 11, 80337 Munich, Germany;(3) Institute of Pathology, Ludwig Maximilians University of Munich, Thalkirchner Str. 36, 80337 Munich, Germany |
| |
Abstract: | Lewis antigens belong to the blood group of antigens and mediate cellular adhesion through interaction with selectins. Invasive trophoblasts use an array of adhesion molecules to facilitate cell–cell and cell–extracellular matrix interactions. Here, we examined immunohistochemically the expression of Sialyl Lewis a (sLea), Sialyl Lewis x (sLex) and Lewis y (Ley) in term placentas obtained from cases of normal, intrauterine growth retardation (IUGR), preeclamptic (PE) and hemolysis, elevated liver enzymes and low platelets syndrome (HELLP) pregnancies. We report the expression of sLex in third trimester extravillous trophoblasts (EVT). sLex was significantly decreased in IUGR and moderately decreased in PE compared to normal placentas. sLex was additionally found in syncytiotrophoblast, without however any significant differences in staining intensity between normal and pathological cases. sLea was restricted to amnion epithelium. Finally, Ley was expressed in cytotrophoblasts and villous endothelial cells. Ley expression was significantly upregulated in IUGR and HELLP, whereas there was a trend toward increase in PE compared to normal placentas. The present study suggests that downregulation of sLex in EVT might be associated with IUGR and PE. Furthermore, Ley, which was recently described as a potent angiogenic factor, is upregulated in placental villi in conditions associated with placental malperfusion. U. Jeschke and A. Makrigiannakis have contributed equally. |
| |
Keywords: | Lewis antigens Trophoblast IUGR Preeclampsia HELLP |
本文献已被 PubMed SpringerLink 等数据库收录! |
|