Co-regulation of the mixed-function oxidation of p-nitroanisole and glucuronidation of p-nitrophenol in the perfused rat liver by carbohydrate reserves |
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Authors: | Ronald G. Thurman Lester A. Reinke Steven Belinsky Roxanne K. Evans Frederick C. Kauffman |
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Affiliation: | 1. Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27514, U.S.A.;2. Department of Pharmacology, University of Maryland, Baltimore, Maryland 21201 U.S.A. |
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Abstract: | Maximal rates of mixed-function oxidation of p-nitroanisole and the glucuronidation of p-nitrophenol in perfused livers from phenobarbital-treated rats varied directly with the nutritional state of the rat (i.e., fasted < fed < fasted-refed). Rates correlated with intracellular concentrations of NADPH, UDP-glucuronic acid, and glycogen but not with amounts of cytochrome P-450 or glucuronyltransferase activity. These data support the hypothesis that mixed-function oxidation and glucuronidation are coregulated in intact cells by carbohydrate-dependent cofactor synthesis. |
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