| Abstract: | Previous studies have shown that the mutT, mutH, mutL and mutS mutators of Escherichia coli confer a marked selective advantage on their respective hosts in competition with otherwise isogenic wild-type strains. We have conducted competition experiments between dam- and dam+ strains of Escherichia coli and have found that dam mutator strains are negatively selected. Although dam- is the first mutator to have a lower fitness than wild-type under chemostat conditions our result does not contradict the hypothesis that increased mutation rates are of evolutionary advantage under environmental stress conditions. Only in the special case of dam- does the advantage of higher mutation rates not outweigh the disadvantage due to the dam- -caused heavy pleiotropic effects. |
