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Activated p53 in the anti-apoptotic milieu of tuberous sclerosis gene mutation induced diseases leads to cell death if thioredoxin reductase is inhibited |
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| Authors: | Abdelwahab ElHusseiny M. M. Bovari-Biri Judit Smuk Gabor Fillinger Janos McPhail Donald Krymskaya Vera P. Pongracz Judit E. |
| Affiliation: | 1.Department of Pharmaceutical Biotechnology, University of Pecs, Pecs, Hungary ;2.Szentagothai Research Centre, University of Pecs, 20 Ifjusag Str., Pecs, 7624, Hungary ;3.Department of Pathology, University of Pecs, Pecs, Hungary ;4.Department of Pathology, Semmelweis University, Budapest, Hungary ;5.National Koranyi Institute of Pulmonology, Budapest, Hungary ;6.Cell Protx Ltd, Aberdeen, UK ;7.Pulmonary, Allergy and Critical Care Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA ;8.Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, University of Pecs, 2 Rokus Str, Pecs, 7624, Hungary ; |
| Abstract: | Apoptosis - Tuberous sclerosis, angiomyolipoma and lymphangioleiomyomatosis are a group of diseases characterized by mutation in tuberous sclerosis genes (TSC 1-2). TSC mutation leads to continuous... |
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