Over-the-Counter-Drug-Induced Thyroid Disorders |
| |
| Institution: | 1. Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center;2. Division of Nuclear Medicine, Beth Israel Deaconess Medical Center;3. Division of Endocrinology, Harvard Vanguard Medical Associates;1. Department of Dermatology, Allergology, and Venereology, Institute of Clinical Medicine, University of Helsinki, Skin and Allergy Hospital, Helsinki University Central Hospital, Helsinki, Finland;2. Division of Endocrinology, Department of Medicine, College of Human Medicine, Michigan State University, East Lansing, Michigan |
| |
| Abstract: | ObjectiveExcessive iodine ingestion may cause thyroid dysfunction. In this case series, we report four patients who developed significant thyroid dysfunction after ingesting over-the-counter (OTC) drugs containing large concentrations of iodine.MethodsFour patients from a tertiary medical center are reported.ResultsCase 1 involved acute exacerbation of thyrotoxicosis induced by taking OTC Tri-iodine? in a 35-year-old woman while still on methimazole therapy. Case 2 involved thyroid-extract-induced thyrotoxicosis following ingestion of Thyromine?, and was confirmed by laboratory studies and 131I thyroid uptake. Cases 3 and 4 involved severe, symptomatic hypothyroidism induced in 2 patients with underlying autoimmune thyroiditis (Hashimoto?s disease) following ingestion of Iodoral?. In all cases, thyroid dysfunction resolved with appropriate management and discontinuation of the OTC drugs.ConclusionThese case reports demonstrate the significant risks associated with OTC preparations containing iodine in patients predisposed to thyroid dysfunction. There is no valid reason for taking high-dose OTC iodine supplements, which have been shown to cause harm and have no known benefit. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
