Novel Biodegradable Polyester Poly(Propylene Succinate): Synthesis and Application in the Preparation of Solid Dispersions and Nanoparticles of a Water-Soluble Drug |
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| Authors: | Dimitrios N Bikiaris George Z Papageorgiou Sofia A Papadimitriou Evangelos Karavas Konstantinos Avgoustakis |
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| Institution: | (1) Laboratory of Organic Chemical Technology, Chemistry Department, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece;(2) Pharmathen S.A., Pharmaceutical Industry, Dervenakion Str 6, Pallini Attikis, 153 51 Attica, Greece;(3) Laboratory of Pharmaceutical Technology, Department of Pharmacy, University of Patras, Rio, 26500 Patras, Greece |
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| Abstract: | Poly(propylene succinate) (PPSu) polymers of average molecular weights from 2,800 to 13,100 g/mol were synthesized and characterized
with regard to crystallinity, thermal properties, and cytocompatibility. Higher molecular weight samples exhibited lower degree
of crystallinity and melted at lower temperatures. Melting of the polymer appeared to begin at 38°C. PPSu cytocompatibility
was investigated based on human umbilical vein endothelial cells viability in the presence of increasing concentrations of
polymer, and it was found that PPSu exhibited comparable cytocompatibility with poly(dl-lactide). The feasibility of applying PPSu as a drug carrier was shown for the first time, as solid dispersions and nanoparticles
of sodium fluvastatin based in PPSu were prepared. Drug release rates decreased with increasing the molecular weight of PPSu
in both solid dispersions and nanoparticles. For dispersions prepared from PPSu of the same molecular weight, drug release
rates increased with drug loading. It appears that PPSu applicability as a drug carrier warrants further consideration. |
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| Keywords: | fluvastatin melt mixing nanoparticles poly(propylene succinate) solid dispersions |
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