Hydrolysis of cocaine in human plasma by cholinesterase. |
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| Authors: | D J Stewart T Inaba B K Tang W Kalow |
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| Affiliation: | Department of Pharmacology, University of Toronto, Toronto M5S 1A8 Canada |
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| Abstract: | Hydrolysis of cocaine to ecgonine methyl ester in human plasma is mediated by cholinesterase. Cocaine hydrolysis by plasma is blocked by DFP and eserine and partially inhibited by fluoride. Highly purified cholinesterase from human plasma when diluted to the same benzoylcholine hydrolyzing activity as human plasma, shows the same rate of cocaine hydrolysis as human plasma. There was no detectable enzymatic conversion of cocaine to benzoyl ecgonine in plasma. |
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