The complex nature of humanD-locus determinants: Heterogeneity within Dw3 |
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| Authors: | Ella M. van den Berg-Loonen Trudie de Bruin P. T. A. Schellekens |
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| Affiliation: | (1) Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam, The Netherlands;(2) Laboratory for Clinical and Experimental Immunology, University of Amsterdam, Amsterdam, The Netherlands |
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| Abstract: | The HLA-A and B homozygous cell, ABR, was found to be mutually nonstimulatory with Dw3-homozygous test cell 16001 (EB), and so was considered to be Dw3-homozygous. However, family studies revealed a difference in theD-locus determinant(s) inherited from the father and mother. The cells carrying the determinants derived from the paternal1,8 haplotype (af) consistently stimulated the lymphocytes bearing the determinants from the maternal1,8 haplotype (ainm), but theam haplotype products could not stimulate those of haplotypeaf. Sinceam is included inaf, cell ABR behaves in population studies as a Dw3-homozygous cell. Typing forD-locus determinants showed the father to be Dw3-positive, the mother Dw3-negative. The Dw3 determinant seems not homogeneous and this should be taken into account in explaining the results withD-locus homozygous typing cells. |
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