Expression of a truncated v-myb product in transformed chicken embryo fibroblasts |
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| Authors: | C Kryceve-Martinerie J Soret J Crochet M Baluda B Perbal |
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| Affiliation: | 1. Institut Curie, Section de Biologie, 91405 Orsay, France;2. Department of Pathology, UCLA School of Medicine, Los Angeles, CA 90024, USA |
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| Abstract: | Transformed cells have been isolated after transfection of chicken embryo fibroblasts (CEF) with the DNA of a recombinant clone (KXA 3457) in which the v-myb sequences are flanked by the two AMV-LTRs. Abnormal myb-specific RNA species and myb-related polypeptides were found to be expressed in these cells, suggesting that transformation of CEF by v-myb might require alterations of the oncogene product. |
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