Antimicrobial Properties of an Oxidizer Produced by Burkholderia cenocepacia P525 |
| |
Authors: | William J Hunter Dan K Manter |
| |
Institution: | 1. Soil-Plant-Nutrient Research Unit, USDA-ARS, Fort Collins, CO, 80526-8119, USA
|
| |
Abstract: | A compound with both oxidizing properties and antibiotic properties was extracted and purified from broth cultures of Burkholderia cenocepacia strain P525. A four step purification procedure was used to increase its specific activity ~400-fold and to yield a HPLC–UV chromatogram containing a single major peak. Size exclusion chromatography suggests a molecular mass of ~1,150 and UV spectroscopy suggests the presence of a polyene structure consisting of as many as six conjugated double bonds. Biological studies indicate that the compound is bacteriostatic. Enterobacter soli and E. aerogenes cells incubated with the compound exhibit a longer lag phase of growth. The bacteriostatic activity is greater at pH 3 than at pH 5. Bacteria such as B. cenocepacia strain P525 may have value in the agricultural industry as biocontrol agents. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|