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The human serum albumin gene: structure of a unique locus |
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| Authors: | J W Hawkins A Dugaiczyk |
| Institution: | Department of Cell Biology, Baylor College of Medicine, Texas Medical Center, Houston, TX 77030 U.S.A. |
| Abstract: | The entire gene for human serum albumin (HSA) has been isolated from a genomic DNA library, carried in the lambda Charon 4A vector. Six independent isolates have been found to hybridize to a cloned HSA cDNA probe, and all six clones share restriction site sequence homology in the overlapping portion of their DNA. These results seem to indicate that the albumin gene is single-copy, or unique, within the human haploid genome. Measuring from the "CAP" site to the "poly(A)" addition site, albumin gene comprises 16.5 kb of DNA. |
| Keywords: | Human gene family unique gene recombinant phage genomic library CAP site position of 5′-terminal 7-methyl-guanosine modification of mRNA HSA human serum albumin kb kilobase pairs |
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