(1) Department of Anatomy, College of Medicine, University of Arizona, Tucson, Arizona, USA;(2) Department of Anatomy, College of Medicine, University of Arizona, 85724 Tucson, Arizona, USA
Abstract:
Summary The indirect immunoperoxidase method was used to identify albumin in hepatocytes of rats before and after periods of starvation. All hepatocytes in fed rats contained a relatively large amount of nascent albumin. Overnight fasting reduced the number of hepatocytes with a large amount of albumin to primarily those surrounding terminal hepatic venules. These were estimated to be about 30% of the population. The other cells had only a slight amount of albumin. After 48 h of fasting all hepatocytes contained a low level of albumin.