Molecular interactions of hormonal steroids: the participation of the 17 side chain of corticosteroids in the formation of complexes with Co (II.). II |
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Authors: | C H Eger C Yarborough M Greiner D A Norton |
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Institution: | The Medical Foundation of Buffalo 73 High Street Buffalo, New York 14203, USA |
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Abstract: | The c20-c21 α-ketol system of the 176 side chain of deoxycorti-costerone is in equilibrium with its c20-c21 enediol. The apparent dissociation constant of this enol was determined by a photometric method using crystal violet indicator; p Ka1 = 10.65 ± 044. Formation constants of the (1:1) deoxycorticosterone-cobalt (II) complex were determined by solvent extraction and in mixed solvent systems. The complex formation constant Kf in an aqueous medium was found by graphical extrapolation to be 2.5–3.0 × 10−1 1. mole−1 |
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