Studies on thiol proteinase inhibitors in rat peripheral blood cells |
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| Authors: | E Kominami T Tsukahara K Ii K Hizawa N Katunuma |
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| Institution: | 1. Department of Enzyme Chemistry, Institute for Enzyme Research The University of Tokushima, Tokushima 770, Japan;1. Department of Pathology, School of Medicine, The University of Tokushima, Tokushima 770, Japan |
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| Abstract: | The concentrations of two types of endogenous thiol proteinase inhibitors, TPI-alpha and TPI-beta, in rat peripheral blood cells were determined by sensitive immunoassay methods. The concentration of TPI-alpha was highest in neutrophils among the peripheral blood cells tested. On the contrary, the concentration of TPI-beta was highest in macrophages followed in order by neutrophils, lymphocytes and erythrocytes. The serum level of TPI-beta was 47 times that of TPI-alpha. Immunohistochemical studies showed that in rat liver, TPI-beta was localized in Kupfer cells, and that only little TPI-alpha was present in liver tissue. |
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| Keywords: | IgG Immunogloburin G Fab′ monovalent tragments derived from pepsin-treated IgG |
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