| 中枢神经损伤后影响轴突再生的因素 |
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| 作者姓名： | Zhao M Liu SJ |
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| 作者单位： | 军事医学科学院基础医学研究所神经生物学研究室,北京100850 |
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| 基金项目： | 国家 973课题基金 (0 0 1CB 5 10 2 0 6 ),国家基金委主任基金(30 14 0 0 0 1)资助课题 |
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| 摘 要： | 与周围神经不同 ,成年哺乳动物中枢神经损伤后轴突不能再生 ,往往造成不可逆的功能丧失。影响再生的原因相当复杂 ,胶质瘢痕形成、神经营养因子缺乏及存在诸多的抑制性因子等。本文就一些影响中枢神经再生的因子从其结构、分布、功能及可能的作用机制诸方面作一综述
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| 关 键 词： | 损伤轴突 轴突再生 胶质瘢痕 |
Factors influencing axon regeneration after CNS damage |
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| Zhao M,Liu SJ.Factors influencing axon regeneration after CNS damage[J].Progress in Physiological Sciences,2004,35(2):107-112. |
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| Authors: | Zhao Min Liu Shao-Jun |
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| Institution: | Department of Neurobiology, Institute of Basic Medical Science, Academy of Military Medical Science, Beijing 100850. |
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| Abstract: | In contrast to peripheral nerves, damaged axons in the mature mammalian brain and spinal cord rarely regenerate, and always lead to permanent loss of function. There are many reasons that inhibit the axon regeneration in the central nerve system, including the formation of glial scar, the deficiency of neurotrophic factors and the expression of inhibitory molecules. Here several factors, their structures, distributions, contributions and possible mechanisms are briefly reviewed. |
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| Keywords: | Damaged axon Axon regeneration Glial scar |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ |
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