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GSK137, a potent small-molecule BCL6 inhibitor with in vivo activity,suppresses antibody responses in mice |
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| Authors: | Andrew C. Pearce Mark J. Bamford Ruth Barber Angela Bridges Maire A. Convery Constantinos Demetriou Sian Evans Thomas Gobbetti David J. Hirst Duncan S. Holmes Jonathan P. Hutchinson Sandrine Jayne Larissa Lezina Michael T. McCabe Cassie Messenger Joanne Morley Melissa C. Musso Paul Scott-Stevens Ana Sousa Manso Jennifer Schofield Tom Slocombe Don Somers Ann L. Walker Anastasia Wyce Xi-Ping Zhang Simon D. Wagner |
| Affiliation: | 1.GlaxoSmithKline, Medicines Research Centre, Stevenage, UK;2.Leicester Drug Discovery and Diagnostics, University of Leicester, Leicester, UK;3.Leicester Cancer Research Centre and Ernest and Helen Scott Haematological Research Unit, University of Leicester, Leicester, UK;4.GlaxoSmithKline, Collegeville, Pennsylvania, USA |
| Abstract: | |
| Keywords: | lymphoma autoimmunity drug discovery immunology lymphocyte BCL6 BCL6 inhibitor antibody response |