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GSK137, a potent small-molecule BCL6 inhibitor with in vivo activity,suppresses antibody responses in mice |
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| Authors: | Andrew C Pearce Mark J Bamford Ruth Barber Angela Bridges Maire A Convery Constantinos Demetriou Sian Evans Thomas Gobbetti David J Hirst Duncan S Holmes Jonathan P Hutchinson Sandrine Jayne Larissa Lezina Michael T McCabe Cassie Messenger Joanne Morley Melissa C Musso Paul Scott-Stevens Ana Sousa Manso Jennifer Schofield Tom Slocombe Don Somers Ann L Walker Anastasia Wyce Xi-Ping Zhang Simon D Wagner |
| Institution: | 1.GlaxoSmithKline, Medicines Research Centre, Stevenage, UK;2.Leicester Drug Discovery and Diagnostics, University of Leicester, Leicester, UK;3.Leicester Cancer Research Centre and Ernest and Helen Scott Haematological Research Unit, University of Leicester, Leicester, UK;4.GlaxoSmithKline, Collegeville, Pennsylvania, USA |
| Abstract: | |
| Keywords: | lymphoma autoimmunity drug discovery immunology lymphocyte BCL6 BCL6 inhibitor antibody response |