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A Trp in chi space |
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| Authors: | DC Horwell MJ McKiernan D Naylor and SA Osborne |
| Institution: | (1) Parke-Davis Neuroscience Research Centre, Cambridge University, Forvie Site, Robinson Way, Cambridge, CB2 2QB, U.K.;(2) Present address: Faculté de Pharmacie, 15 Avenue Charles Flahault, 34060 Montpellier, Cedex, France |
| Abstract: | Our aim is to identify and synthesise a  family of tryptophan mimetics which thoroughly explore chi space and then incorporate them into selected ligands for biological receptors e.g. Tachykinin NK1. This project is considered important as only the  - angles have previously been explored; obtaining a greater understanding of the spacial orientation of the side chain in chi space ( 1-2) should prove invaluable to the future design of peptidomimetics. The amino acid tryptophan was selected as it has proved pivotal in many pharmaceutic drug programmes. |
| Keywords: | bombesin cholecystokinin conformational constraints novel tryptophan derivatives tachykinin |
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