Gerronemins A-F, cytotoxic biscatechols from a Gerronema species |
| |
Authors: | Silberborth Sven Stumpf Anja Erkel Gerhard Anke Timm Sterner Olov |
| |
Affiliation: | Lehrbereich Biotechnologie der Universit?t, Paul-Ehrlich-Strabetae 23, D-67663 Kaiserslautern, Germany. |
| |
Abstract: | The gerronemins A-F (1-6) were isolated as the cytotoxic components of an extract of a Gerronema species detected in a screening for new cytotoxic metabolites from basidiomycetes. Their structures were elucidated by spectroscopic techniques, and they are composed of a C12-C16 alkane or alkene substituted at both ends by 2,3-dihydroxyphenyl groups. The gerronemins blocked the inducible expression of a hCOX-2 and iNOS promoter driven reporter gene with IC50-values of 1-5 microg/ml. In addition, cytotoxic activities were observed which were due the inhibition of cellular macromolecular syntheses. |
| |
Keywords: | Gerronema Gerronemins A-F Biscatechols Cytotoxic activity |
本文献已被 ScienceDirect PubMed 等数据库收录! |