Therapeutic angiogenesis for severe ischemic heart diseases by autologous bone marrow cells transplantation |
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| Authors: | Reiji Hattori Hiroaki Matsubara |
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| Institution: | (1) Department of Biochemistry, University of Madras, Guindy Campus, Chennai, India;(2) 62, New No. 66, Gandhinagar, Adyar, Chennai, India |
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| Abstract: | The effects of exogenous histone H1 on estrogen receptor status of human breast cancer MCF 7 cells were investigated in presence and absence of estrogen. Exogenous histone H1 was significantly cytotoxic in a dose- and time-dependent manner. Cell cycle analysis revealed a significant increase in the percentage of cell accumulation in G0/G1 phase. In histone H1-treated cells, a significant decrease in the estrogen receptor content and an increase in the dissociation constant (KD) of ER was observed compared to control. |
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| Keywords: | breast cancer cell cycle estrogen receptor histone H1 MCF 7 cells |
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