|
|||||
|
|
Synthesis of 1-D-6-O-[2-(N-hydroxyaminocarbonyl)amino-2-deoxy-alpha-D-glucopyranosyl]-myo-inositol 1-(n-octadecyl phosphate): a potential metalloenzyme inhibitor of glycosylphosphatidylinositol biosynthesis |
|
| Authors: | Crossman Arthur T Urbaniak Michael D Ferguson Michael A J |
| Affiliation: | Division of Biological Chemistry and Drug Discovery, College of Life Sciences, The University of Dundee, DD1 5EH Dundee, Scotland, United Kingdom. |
| Abstract: | 1-D-6-O-[2-(N-hydroxyaminocarbonyl)amino-2-deoxy-alpha-D-glucopyranosyl]-myo-inositol 1-(n-octadecyl phosphate) was prepared to probe the reaction mechanism of the putative zinc-dependent metalloenzyme 2-acetamido-2-deoxy-alpha-D-glucopyranosyl-(1-->6)-phosphatidylinositol de-N-acetylase of glycosylphosphatidylinositol biosynthesis. |
| Keywords: | Glycosylphosphatidylinositol (GPI) membrane anchors N-Hydroxyurea Zinc metalloenzyme inhibitor N-Acetyl- smallcaps" >d-glucosaminylphosphatidylinositol de-N-acetylase |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |