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Synthesis of 1-D-6-O-[2-(N-hydroxyaminocarbonyl)amino-2-deoxy-alpha-D-glucopyranosyl]-myo-inositol 1-(n-octadecyl phosphate): a potential metalloenzyme inhibitor of glycosylphosphatidylinositol biosynthesis |
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| Authors: | Crossman Arthur T Urbaniak Michael D Ferguson Michael A J |
| Institution: | Division of Biological Chemistry and Drug Discovery, College of Life Sciences, The University of Dundee, DD1 5EH Dundee, Scotland, United Kingdom. |
| Abstract: | 1-D-6-O-2-(N-hydroxyaminocarbonyl)amino-2-deoxy-alpha-D-glucopyranosyl]-myo-inositol 1-(n-octadecyl phosphate) was prepared to probe the reaction mechanism of the putative zinc-dependent metalloenzyme 2-acetamido-2-deoxy-alpha-D-glucopyranosyl-(1-->6)-phosphatidylinositol de-N-acetylase of glycosylphosphatidylinositol biosynthesis. |
| Keywords: | Glycosylphosphatidylinositol (GPI) membrane anchors N-Hydroxyurea Zinc metalloenzyme inhibitor d-glucosaminylphosphatidylinositol de-N-acetylase" target="_blank">N-Acetyl-d-glucosaminylphosphatidylinositol de-N-acetylase |
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