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Intrathecal lidocaine pretreatment attenuates immediate neuropathic pain by modulating Nav1.3 expression and decreasing spinal microglial activation
Authors:Kuang-I Cheng  Chung-Sheng Lai  Fu-Yuan Wang  Hung-Chen Wang  Lin-Li Chang  Shung-Tai Ho  Hung-Pei Tsai and Aij-Li Kwan
Institution:(1) Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;(2) Department of Anesthesiology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;(3) Department of Anesthesiology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;(4) Department of Surgery, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;(5) Division of Plastic and Reconstructive Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;(6) Department of Neurosurgery, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan;(7) Department of Microbiology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;(8) Department of Anesthesiology, Tri-Service General Hospital National Defense Medical Center, Taipei, Taiwan;(9) Department of Neurosurgery, Kaohsiung Medical University, Kaohsiung, Taiwan
Abstract:

Background  

Intrathecal lidocaine reverses tactile allodynia after nerve injury, but whether neuropathic pain is attenuated by intrathecal lidocaine pretreatment is uncertain.
Keywords:
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