Glutathione S-transferase T1 polymorphism is associated with breast cancer susceptibility |
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Authors: | Chen Xing-Xing Zhao Ru-Ping Qiu Li-Xin Yuan Hui Mao Chen Hu Xi-Chun Guo Xiao-Mao |
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Institution: | aDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China;bDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, China;cDepartment of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China;dDepartment of Preventive Medicine, Wannan Medical College, Wuhu, China;eDivision of Epidemiology, School of Public Health and Primary Care, the Chinese University of Hong Kong, Hong Kong, China |
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Abstract: | The association between present/null polymorphism of glutathione S-transferase T1 (GSTT1) and breast cancer risk are still inconclusive. We performed a meta-analysis to derive a more precise estimation of the relationship. A total of 48 studies including 17,254 cases and 21,163 controls were involved in this meta-analysis. When all studies were pooled into the meta-analysis, significantly elevated breast cancer risk was associated with null genotype (OR = 1.138, 95% CI = 1.051–1.232). When stratified by ethnicity, significantly increased risks were found for Caucasians (OR = 1.185, 95% CI = 1.075–1.306), but no statistically significantly increased risks were found in Asians (OR = 1.017, 95% CI = 0.846–1.223) and Africans (OR = 1.160, 95% CI = 0.815–1.650). In the subgroup analysis by controls source, statistically significantly elevated risks were both found in population-based studies (OR = 1.123, 95% CI = 1.014–1.243) and hospital-based studies (OR = 1.181, 95% CI = 1.056–1.321). When stratified by menopausal status, no statistically significantly increased risks were found in premenopausal women (OR = 1.115, 95% CI = 0.925–1.345) and postmenopausal women (OR = 1.077, 95% CI = 0.992–1.169). In summary, this meta-analysis suggests that the GSTT1 null genotype is a risk allele for breast cancer development. However, large sample and representative population-based studies with homogeneous breast cancer patients and well matched controls are warranted to confirm this finding. |
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Keywords: | GSTT1 Polymorphism Breast cancer Susceptibility |
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