A histone deacetylase regulates addiction |
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| Authors: | Impey Soren |
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| Affiliation: | Department of Cell and Developmental Biology, Oregon Health & Sciences University, Portland, OR 97239, USA. impeys@ohsu.edu |
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| Abstract: | Epigenetic modification of chromatin has been proposed to translate environmental stimuli into persistent "cellular memories." Recent studies suggest that epigenetic pathways regulate long-term behavioral adaptation in the nervous system. In this issue of Neuron, Renthal et al. utilize genetic manipulations of HDAC5 to provide strong evidence for a role for histone acetylation in the behavioral response to cocaine. |
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