Induction of a 'stress' protein in intact mammalian organs after the intravenous administration of sodium arsenite |
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Authors: | I R Brown S J Rush |
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Affiliation: | Department of Zoology, University of Toronto, Scarborough Campus West Hill, Ontario, Canada M1C 1A4 |
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Abstract: | The profile of nascent proteins synthesized in various rabbit organs after the intravenous injection of sodium arsenite was analyzed by the cell-free translation of purified polysomes. Examination of the translation products of polysomes isolated 1 hr after injection of sodium arsenite revealed a marked induction of synthesis of a protein of molecular weight 74,000 (74K) in the kidney, heart and liver which was similar to a 'heat shock' protein which was induced in these organs after elevation of body temperature by 2.5 to 3 degrees C. Synthesis of the 74K protein was not detected in the translation products of brain polysomes isolated 1 hr after sodium arsenite injection. |
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