Rapid screening of Aspergillus terreus mutants for overproduction of lovastatin |
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| Authors: | M. A. Vilches Ferrón J. L. Casas López J. A. Sánchez Pérez J. M. Fernández Sevilla Y. Chisti |
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| Affiliation: | (1) Department of Chemical Engineering, University of Almería, 04120 Almería, Spain;(2) Institute of Technology and Engineering, Massey University, Palmerston North, New Zealand |
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| Abstract: | Summary A novel rapid screening method is demonstrated for isolating lovastatin-overproducing strains of Aspergillus terreus. The screening methodology, based on the activity of lovastatin against the yeast Candida albicans, is nearly three times as fast as the selection methods used earlier. The new 6-h assay shows a linear correlation between the quantity of lovastatin generated by A. terreus isolates and the inhibition zones obtained on plates of C. albicans. The new technique is less expensive and requires less labour. |
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| Keywords: | Aspergillus terreus Candida albicans lovastatin mutation screening |
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