Reserve of vasopressin-sensitive adenylate cyclase in toad urinary bladder |
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Authors: | Jorge Flores Patricia Witkum Barbara Beckman Geoffrey W.G. Sharp |
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Affiliation: | 1. Departments of Medicine and Physiology from the Massachusetts General Hospital and Harvard Medical School, Boston, Mass. U.S.A. |
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Abstract: | Studies have been performed on the effect of vasopressin on cyclic AMP content of toad bladders. A prompt increase in cyclic AMP content occurred after exposure to vasopressin, which reached maximal values within 8 min and remained elevated up to 30 min. By a comparison of the dose-response characteristics of vasopressin on cyclic AMP content, with those Na+ transport and osmotic water flow, it was shown that supramaximal concentrations of vasopressin with respect to physiological function generate more cyclic AMP than is required for maximal stimulation of Na+ transport and water flow. Thus, it would seem that a reverse of hormone-sensitive adenylate cyclase is present in this tissue. |
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