Effects of glucocorticoids and catecholamines on maturing rat heart |
| |
| Authors: | Z J Penefsky |
| |
| Affiliation: | Department of Physiology and Biophysics, Mount Sinai School of Medicine of the City University of New York 10029. |
| |
| Abstract: | 1. The negative force-frequency response of normal rat heart was accentuated when the animals were adrenalectomized. Treatment of adrenalectomized animals with dexamethasone restored the normal force-frequency response. 2. Total adrenalectomy increased the sensitivity of rat heart to calcium. 3. Adrenalectomized-dexamethasone-treated hearts were more responsive to epinephrine and ouabain. 4. Total adrenalectomy caused independent myocardial disturbances in calcium handling elements (glucocorticoid effect) and beta receptors (catecholamine effect). |
| |
| Keywords: | |
|
|
