Lysophosphatidic acid and renal fibrosis |
| |
Authors: | Pradère Jean-Philippe Gonzalez Julien Klein Julie Valet Philippe Grès Sandra Salant David Bascands Jean-Loup Saulnier-Blache Jean-Sébastien Schanstra Joost P |
| |
Affiliation: | Inserm, U858/I2MR, Department of Metabolism and Obesity, Team #3, 1 Avenue Jean Poulhès, BP 84225, 31432 Toulouse Cedex 4, France. |
| |
Abstract: | The development of fibrosis involves a multitude of events and molecules. Until now the majority of these molecules were found to be proteins or peptides. But recent data show significant involvement of the phospholipid lysophosphatidic acid (LPA) in the development of pulmonary, liver and renal fibrosis. The latest data on the role of LPA and the G-protein-coupled LPA1 receptor in the development of renal fibrosis will be discussed. LPA1-receptor activation was found to be associated with increased vascular leakage and increased fibroblast recruitment in pulmonary fibrosis. Furthermore, in renal fibrosis LPA1-receptor activation stimulates macrophage recruitment and connective tissue growth factor expression. The observations make this receptor an interesting alternative and new therapeutic target in fibrotic diseases. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|