Diketopiperazines from marine organisms |
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| Authors: | Huang Riming Zhou Xuefeng Xu Tunhai Yang Xianwen Liu Yonghong |
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| Institution: | 1. Key Laboratory of Marine Bio‐resources Sustainable Utilization/Guangdong Key Laboratory of Marine Materia Medica/Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, P.?R. China, (phone: +86‐20‐89023244;2. fax: +86‐20‐84451672);3. Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, P.?R. China;4. School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, P.?R. China |
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| Abstract: | Diketopiperazines (DKPs), which are cyclic dipeptides, have been detected in a variety of natural resources. Recently, the interest in these compounds increased significantly because of their remarkable bioactivity. This review deals with the chemical structures, biosynthetic pathways, and biological activities of DKPs from marine microorganisms, sponges, sea stars, tunicates (ascidians), and red algae. The literature has been covered up to December 2008, and a total 124 DKPs from 104 publications have been discussed and reviewed. Some of these compounds have been found to possess various bioactivities including cytotoxicity, and antibacterial, antifungal, antifouling, plant-growth regulatory, and other activities. |
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| Keywords: | Piperazines diketo‐ Marine natural products |
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