Direct inhibitory effect of atriopeptin III on renin release in primate kidney |
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| Authors: | W L Henrich E A McAlister P B Smith J Lipton W B Campbell |
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| Affiliation: | 1. Department of Applied Geology, School of Earth and Atmospheric Sciences, University of Madras, Guindy Campus, Chennai, Tamilnadu 600 025, India;2. MOE Key Laboratory of Western China''s Environmental System, College of Earth and Environmental Sciences, Lanzhou University, Lanzhou 730000, PR China;3. Department of Applied Geology, School of Applied Natural Sciences, Adama Science & Technology University, Adama, Ethiopia;4. School of Geography and Planning, Sun Yat-Sen University, Guangzhou 510275, PR China;5. Deogiri College, Aurangabad, Maharashtra, India;1. School of Electrical Engineering and Automation, Jiangsu Normal University, Xuzhou 221116, China;2. Center for Polymer Studies and Department of Physics, Boston University, Boston, MA 02215, USA;3. School of Physical Electronics, University of Electronic Science and Technology of China, Cheng Du 610054, China;1. Division of Cardiovascular Medicine, Kanazawa University, Graduate School of Medicine, Kanazawa, Japan;2. Department of Bioinformatics and Genomics, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan;3. Department of Advanced Research in Community Medicine, Kanazawa University, Graduate School of Medical Sciences, Kanazawa, Japan;4. Department of Laboratory Science, Molecular Biochemistry and Molecular Biology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan;5. Hamajiri Clinic, Takasaki, Japan |
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| Abstract: | Patterns of in vitro renal renin release and the ability of atriopeptin to directly inhibit renin release have been examined in the rat, rabbit, and dog, but have been unstudied in the primate kidney. Accordingly, we examined renin release from superficial renal cortical slices of the squirrel monkey (Samiri sciuresus). The average age of the 5 animals was 10.2 +/- 2.5 yr at the time of study. Renin release was stimulated significantly by the beta-adrenergic agonist isoproterenol in concentrations of 10(-5) M (1.67-fold) and 10(-4) M (1.84-fold). Isoproterenol-induced renin release was inhibited by atriopeptin III (ANP, 2 X 10(-8) M) and the adenylate cyclase inhibitor dideoxadenosine (DDA, 10(-5) M). Similarly, the incubation of the superficial cortical slices with arachidonic acid (10(-3) M) resulted in a 4-fold increase in tissue renin release which was blocked by the calcium ionophore A23187 (17 X 10(-6) M) and ANP; interestingly, DDA did not block arachidonic acid-induced renin release. These results suggest that ANP exerts a direct inhibitory effect on B-adrenergic and arachidonic acid-induced renin release in the primate kidney. Further, the inhibitory action of A23187 on renin release suggests, as in other species, an integral role for intracellular calcium in the renin release process. These patterns of renin release in primate kidney are similar to those observed in the rodent kidney in vitro. |
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