DNA enzymes |
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Authors: | Dipankar Sen C Ronald Geyer |
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Institution: | aInstitute of Molecular Biology and Biochemistry and the Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, V5A 1S6, Canada;bMolecular Sciences Institute, 2168 Shattuck Avenue, 2nd Floor, Berkeley, CA 95704, USA |
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Abstract: | The past year has seen a coming-of-age in DNA enzyme research. Far from being laboratory curiosities, the activities of new DNA enzymes have broadened the known catalytic repertoire of nucleic acid enzymes, provided valuable insights into different mechanistic possiblities open to nucleic acid catalysts, and explored the importance for catalysis of native functionalities within DNA and RNA, as well as of a diversity of extrinsic cofactors. Thus, the first amino acid cofactor-utilizing DNA enzyme has been described, as well as DNA enzymes that cleave RNA without the assistance of any external cofactor. On the practical side, the most efficient RNA-cleaving nucleic acid enzyme described to date is a DNA enzyme. |
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