电针对青霉素所致大脑皮层痫样放电的抑制作用

青霉素置于大鼠大脑皮层感觉运动区所诱发的皮层痫样放电,可被一些“穴位”电针所抑制,表现为放电频率、振幅及时程之减少。青霉素使逆向刺激锥体束所产生的感觉运动皮层表面负波减小,而电针则促进其恢复。因此电针制痫与它促进回返抑制的恢复有关。将微量纳洛酮注入腹腔、脑室及中脑导水管周围灰质、伏隔核均能翻转电针的作用。将纳洛酮直接注入放置青霉素处的皮层感觉运动区,针效亦被阻断。这表明电针制痛中有内啡肽参与。电刺激中脑导水管周围灰质及伏隔核有显著制痫作用。

INHIBITORY EFFECT OF ELECTRO-ACUPUNCTURE ON PENICILLIN-INDUCED CORTICAL EPILEPTIFORM DISCHARGES

Epileptiform discharges induced by topical application of penicillin on rat's-sensory-motor cortex were attenuated after acupuncture of certain "acupoints", asrevealed by reduction of frequency, amplitude and duration of the discharges.Penicillin decreased the surface-negative wave evoked by antidromic stimulationof pyramidal tract, while electroacupuncture facilitated the restoration of suchwave, thus the antiepileptic effect of electro-acupuncture was related to its restora-tion of recurrent inhibition of pyramidal tract. The effect of acupuncture wasreversed by microinjection of naloxone into peritoneal cavity, lateral ventricle,periaqueductal gray of midbrain and N.accumbens. Direct injection of naloxoneinto the cortical site where penicillin was applied also blocked the acupuncturaleffect, thus suggesting the participation of endorphin in antiepileptic action of acu-puncture. A marked antiepileptic effect was observed during stimulation ofperiaqueductal gray of midbrain and N. accumbens.