DNA sequence-specific ligands: XIV. Synthesis of fluorescent biologically active dimeric bisbenzimidazoles DB(3, 4, 5, 7, 11) |
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Authors: | A A Ivanov V I Salyanov S A Strel’tsov N A Cherepanova E S Gromova A L Zhuze |
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Institution: | 1.Research Institute of Carcinogenesis, Blokhin Russian Oncological Research Center,Russian Academy of Medical Sciences,Moscow,Russia;2.Engelhardt Institute of Molecular Biology,Russian Academy of Sciences,Moscow,Russia;3.Chemical Faculty,Moscow State University,Moscow,Russia |
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Abstract: | Five fluorescent symmetrical dimeric bisbenzimidazoles DB(n) containing four 2,6-substituted benzimidazole cores and differing in the length of the oligomethylene linker between two
bisbenzimidazole rings (n = 3, 4, 5, 7, 11) have been synthesized. The ability of the dimeric bisbenzimidazoles to form complexes with the double-stranded
DNA has been shown by spectral methods. Upon binding to the double-stranded DNA, DB(n) are localized in the narrow groove. The data on the inhibition of the DNA methyltransferase Dnmt3a by DB(n) indicate that dimeric bisbenzimidazoles DB(3) and DB(11) site-specifically bind to the oligonucleotide duplex. |
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